BMPR1A

Across TCGA patient cohorts, BMPR1A mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMPR1A-associated genes across cancer lineages are eEF2, FoxM1, and p38-MAPK_pT180_Y182. Each is linked with BMPR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both BMPR1A-to-partner and partner-to-BMPR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by BMPR1A-low versus BMPR1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMPR1A→partner) and Y-score (partner→BMPR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.349	+2.321	.009	.033	3	2
UCEC	FoxM1 →	+0.291	+2.662	.002	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.441	-1.752	.009	.014	3	2
UCEC	PDCD4 →	-0.481	-2.000	.006	.029	3	2
UCEC	Rab25 →	-0.397	-3.321	.001	.009	3	2
UCEC	Rictor_pT1135 →	-0.092	-2.584	.016	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

eEF2 by BMPR1A expression — UCEC

Explore this box plot interactively →