Ubiquitin-dependent glycoprotein ERAD pathway

Across TCGA patient cohorts, RNA activity of the Ubiquitin-dependent glycoprotein ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGHV4-61, TBC1D27P, and FCRL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-dependent glycoprotein ERAD pathway activity versus IGHV4-61 in BRCA (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGHV4-61 →	+1.537	+0.221	.002	.002	3	5
LUAD	TBC1D27P →	+0.330	+0.370	.001	.005	3	4
BRCA	FCRL2 →	+0.580	+0.217	<.001	.002	3	4
GBM	CUL4B →	-0.344	-0.264	.001	<.001	3	4
BRCA	FAM120C →	-0.355	-0.211	<.001	<.001	3	4
BRCA	BTLA →	+0.453	+0.190	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097466 vs IGHV4-61 — BRCA

Explore this scatter interactively →