Ubiquitin-dependent glycoprotein ERAD pathway

Across TCGA pan-cancer cohorts, RNA activity of the Ubiquitin-dependent glycoprotein ERAD pathway pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Ubiquitin-dependent glycoprotein ERAD pathway pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and MESO, show the opposite pattern, with higher activity associated with better survival.

UVM, LGG, and GBM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.232	0.709	.002	72	view →
LGG	DFS	Tertile	All	0.337	0.543	<.001	45	view →
GBM	DFS	Median	All	0.183	0.318	<.001	39	view →
SKCM	OS	Tertile	II,III,IV	0.443	0.209	.002	34	view →
MESO	DFS	Quartile	IV	0.584	0.144	.006	20	view →
READ	OS	Median	II,III,IV	0.811	0.425	.005	18	view →
LUAD	OS	Median	III,IV	0.470	0.165	.007	15	view →
KIRP	OS	Tertile	All	0.545	0.815	.014	14	view →
THCA	DFS	Median	IV	1.000	0.618	.020	12	view →
PCPG	DFS	Tertile	All	1.000	0.671	.004	10	view →
COAD	OS	Quartile	II,III,IV	0.893	0.731	.004	10	view →
SCLC	DFS	Median	III,IV	0.338	0.968	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0097466–UVM (DFS)

Open the UVM breakdown →