GO:0072376Ontology (GO BP)GO biological process · ~19 member genes
Q-omics provides the Protein activation cascade (GO:0072376) pathway profile, scoring each patient from the combined activity of its roughly 19 member genes. Pathway activity is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in STAD. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 10, with the highest sampling consensus in BLCA. Additionally, pathway RNA activity shows 28,495 significant cross-omics associations, again with the highest sampling consensus in PRAD. Together, these results highlight STAD, BLCA, and PRAD as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Protein activation cascade survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Protein activation cascade activity shows favorable associations in ESCA, but unfavorable associations in STAD, READ, UCEC, BRCA and GBM. In the STAD Kaplan–Meier curve the high-activity group declines faster, consistent with the unfavorable association (log-rank p = .001). STAD ranks highest by sampling consensus for Protein activation cascade.
This table summarizes Protein activation cascade tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 10 cancer types, while mass-spec protein activity shows differences in 6. The strongest signals are in BLCA for RNA and LUAD for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows consistently lower tumor activity across BLCA, CHOL, HNSC, LIHC, KICH and LUSC. In the BLCA box plot, normal samples show higher pathway activity than tumor samples (log2 FC = −0.096, t-test p < 0.001).
This table shows molecular features associated with Protein activation cascade pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in PRAD. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in LARGE_INTESTINE.
