Protein activation cascade

Across TCGA patient cohorts, RNA activity of the Protein activation cascade pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NNMT, MRC1, and TAGLN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein activation cascade activity versus NNMT in GBM (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NNMT →	+1.264	+0.099	<.001	<.001	3	9
GBM	MRC1 →	+0.771	+0.101	<.001	<.001	3	8
GBM	TAGLN →	+1.236	+0.124	<.001	<.001	3	7
UCEC	UTP14A →	-0.307	-0.101	<.001	<.001	3	7
GBM	F13A1 →	+0.938	+0.113	<.001	<.001	3	7
OV	RAB31 →	+0.537	+0.077	.004	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072376 vs NNMT — GBM

Explore this scatter interactively →