Protein activation cascade

Across TCGA patient cohorts, RNA activity of the Protein activation cascade pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLX, CXCL12, and ACTA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein activation cascade activity versus HLX in PDAC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HLX →	+0.388	+0.262	<.001	.003	3	8
BRCA	CXCL12 →	+1.398	+0.269	<.001	<.001	3	7
OV	ACTA2 →	+1.327	+0.128	<.001	<.001	3	7
OV	SPARC →	+1.265	+0.177	<.001	<.001	3	7
OV	CCN2 →	+1.626	+0.201	<.001	<.001	3	7
OV	AOC3 →	+1.088	+0.152	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072376 vs HLX — PDAC

Explore this scatter interactively →