Protein activation cascade

Across TCGA cell cohorts, RNA activity of the Protein activation cascade pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K8, SLC52A2, and USP51, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP3K8 grouped by Protein activation cascade-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MAP3K8 →	-0.151	-0.337	.006	.005	3	4
BREAST	SLC52A2 →	-0.147	-0.294	<.001	<.001	3	4
KIDNEY	USP51 →	+0.492	+0.426	.007	.007	3	3
BLOOD_Myeloma	TNS1 →	+0.250	+0.457	.002	.006	3	3
LUNG_NSCLC_LUAD	GCLM →	+0.123	+0.322	.009	.001	3	3
OVARY	PPP1R14B →	-0.210	-0.384	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP3K8 by Protein activation cascade activity — PANCREAS

Explore this box plot interactively →