Protein activation cascade

Across TCGA cell cohorts, RNA activity of the Protein activation cascade pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC36A1, PPP1R12A, and PKN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC36A1 grouped by Protein activation cascade-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC36A1 →	-0.113	-0.187	.008	.003	3	7
PANCREAS	PPP1R12A →	+0.497	+0.354	<.001	<.001	3	7
PANCREAS	PKN2 →	+0.226	+0.373	.003	<.001	3	7
BREAST	TLN1 →	+0.332	+0.268	.001	.001	3	7
SKIN	CRK →	+0.190	+0.178	.001	.004	3	6
BLOOD_Leukemia	SPOCD1 →	-0.150	-0.083	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC36A1 by Protein activation cascade activity — LARGE_INTESTINE

Explore this box plot interactively →