Protein activation cascade

Across TCGA cell cohorts, RNA activity of the Protein activation cascade pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHG1, PLBD2, and ANXA2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein activation cascade activity versus PLEKHG1 in OVARY (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PLEKHG1 →	-2.043	-0.441	<.001	<.001	3	7
OVARY	PLBD2 →	+0.819	+0.348	.006	.008	3	6
BLOOD_Lymphoma	ANXA2 →	+2.516	+0.350	<.001	<.001	2	7
BLOOD_Lymphoma	MVP →	+3.275	+0.414	<.001	<.001	3	6
OVARY	FOSL1 →	+3.532	+0.457	.003	.003	3	6
BONE	N4BP2 →	-1.141	-0.373	.006	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072376 vs PLEKHG1 — OVARY

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