GO:0018410Ontology (GO BP)GO biological process · ~13 member genes
Q-omics provides the C-terminal protein amino acid modification (GO:0018410) pathway profile, scoring each patient from the combined activity of its roughly 13 member genes. Pathway activity is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 8, with the highest sampling consensus in KIRC. Additionally, pathway RNA activity shows 35,966 significant cross-omics associations, again with the highest sampling consensus in STAD. Together, these results highlight COAD, KIRC, and STAD as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes C-terminal protein amino acid modification survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High C-terminal protein amino acid modification activity shows favorable associations in COAD, LIHC, CHOL, SARC and KIRP, but unfavorable associations in MESO. In the COAD Kaplan–Meier curve the low-activity group declines faster, consistent with the favorable association (log-rank p = .001). COAD ranks highest by sampling consensus for C-terminal protein amino acid modification.
This table summarizes C-terminal protein amino acid modification tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 8 cancer types, while mass-spec protein activity shows differences in 1. The strongest signals are in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across KIRC, PRAD and UCEC and lower tumor activity in BRCA, HNSC and THCA. In the KIRC box plot, tumor samples show higher pathway activity than matched normal samples (log2 FC = +0.065, t-test p < 0.001).
This table shows molecular features associated with C-terminal protein amino acid modification pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in STAD. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in SOFT_TISSUE.
