C-terminal protein amino acid modification

Across TCGA cell cohorts, RNA activity of the C-terminal protein amino acid modification pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA7A, KDELR1, and LAMP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEMA7A grouped by C-terminal protein amino acid modification-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SEMA7A →	-0.388	-0.108	.001	.002	3	6
LUNG_NSCLC_LUSC	KDELR1 →	-0.186	-0.167	.001	.004	3	6
UPPER_AERODIGESTIVE_TRACT	LAMP3 →	-0.194	-0.147	.001	.001	3	5
LIVER	POLM →	+0.538	+0.317	.001	<.001	3	5
LARGE_INTESTINE	ATP10D →	-0.264	-0.127	<.001	.004	3	4
SOFT_TISSUE	CT55 →	+0.331	+0.108	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEMA7A by C-terminal protein amino acid modification activity — SOFT_TISSUE

Explore this box plot interactively →