C-terminal protein amino acid modification

Across TCGA cell cohorts, RNA activity of the C-terminal protein amino acid modification pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG12, AGTPBP1, and SOX6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATG12 grouped by C-terminal protein amino acid modification-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATG12 →	-0.218	-0.700	<.001	.006	2	9
OVARY	AGTPBP1 →	-0.193	-1.233	.002	.002	3	7
LUNG_SCLC	SOX6 →	-0.256	-0.992	.002	.008	3	6
BLOOD_Myeloma	ATG7 →	-0.317	-1.298	.002	.003	3	6
BREAST	FOLH1B →	-0.204	-0.951	<.001	<.001	3	5
BREAST	LCMT1 →	-0.198	-0.781	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATG12 by C-terminal protein amino acid modification activity — BREAST

Explore this box plot interactively →