C-terminal protein amino acid modification

Across TCGA patient cohorts, RNA activity of the C-terminal protein amino acid modification pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LEMD2_S497, PTGES3_S85, and PHF6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C-terminal protein amino acid modification activity versus LEMD2_S497 in PDAC (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LEMD2_S497 →	-0.450	-0.043	.004	<.001	3	4
PDAC	PTGES3_S85 →	-0.585	-0.042	.001	.003	3	4
LSCC	PHF6 →	+0.342	+0.055	.001	<.001	3	4
OV	APLP2 →	-0.445	-0.040	<.001	.002	3	4
HNSC	ZMYM3_S464 →	+0.244	+0.039	.005	.007	3	4
CCRCC	ARPC4 →	+0.195	+0.058	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018410 vs LEMD2_S497 — PDAC

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