C-terminal protein amino acid modification

Across TCGA cell cohorts, RNA activity of the C-terminal protein amino acid modification pathway is significantly associated with the total protein of multiple features, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are GATA3, STAT5a, and c-Jun_pS73, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C-terminal protein amino acid modification activity versus GATA3 in BREAST (Pearson r = 0.67).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GATA3 →	+3.247	+0.165	.025	.028	2	2
CNS	STAT5a →	-0.665	-0.300	.007	.017	3	1
BREAST	c-Jun_pS73 →	-0.256	-0.165	.007	.028	2	1
CNS	S6_pS235_S236 →	+1.145	+0.381	.011	.044	2	1
BREAST	Bid →	+0.119	+0.165	.008	.028	1	1
CNS	14-3-3_beta →	+0.195	+0.300	.035	.017	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018410 vs GATA3 — BREAST

Explore this scatter interactively →