C-terminal protein amino acid modification

Across TCGA patient cohorts, RNA activity of the C-terminal protein amino acid modification pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGTPBP1, ATG7, and DOCK2, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C-terminal protein amino acid modification activity versus AGTPBP1 in DLBC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	AGTPBP1 →	+1.161	+0.060	<.001	<.001	3	29
ACC	ATG7 →	+0.648	+0.040	.002	.001	1	30
THYM	DOCK2 →	+1.312	+0.049	<.001	<.001	3	27
UVM	PTPRC →	+1.363	+0.050	<.001	<.001	3	27
UVM	ARHGAP30 →	+1.500	+0.058	<.001	<.001	2	27
TGCT	CSF2RB →	+1.081	+0.041	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018410 vs AGTPBP1 — DLBC

Explore this scatter interactively →