GO:0006501Ontology (GO BP)GO biological process · ~5 member genes
Q-omics provides the C-terminal protein lipidation (GO:0006501) pathway profile, scoring each patient from the combined activity of its roughly 5 member genes. Pathway activity is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 9, with the highest sampling consensus in BLCA. Additionally, pathway RNA activity shows 35,178 significant cross-omics associations, again with the highest sampling consensus in STAD. Together, these results highlight LUAD, BLCA, and STAD as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes C-terminal protein lipidation survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (25). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High C-terminal protein lipidation activity shows favorable associations in COAD and ESCA, but unfavorable associations in LUAD, STAD, UVM and LUSC. In the LUAD Kaplan–Meier curve the high-activity group declines faster, consistent with the unfavorable association (log-rank p = .001). LUAD ranks highest by sampling consensus for C-terminal protein lipidation.
This table summarizes C-terminal protein lipidation tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 9 cancer types. The strongest signals are in BLCA for RNA.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across BLCA, LIHC, BRCA and KIRC and lower tumor activity in HNSC and LUSC. In the BLCA box plot, tumor samples show higher pathway activity than matched normal samples (log2 FC = +0.039, t-test p < 0.001).
This table shows molecular features associated with C-terminal protein lipidation pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in STAD. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in LIVER.
