C-terminal protein lipidation

Across TCGA patient cohorts, RNA activity of the C-terminal protein lipidation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSORS1C3, TRMT10A, and MAST1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C-terminal protein lipidation activity versus PSORS1C3 in UCEC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSORS1C3 →	+1.138	+0.184	.007	.004	3	3
LSCC	TRMT10A →	-0.295	-0.141	.006	.001	3	3
BRCA	MAST1 →	-0.584	-0.087	.004	.004	3	3
BRCA	CRTAM →	+0.528	+0.095	.005	.001	3	3
BRCA	KMO →	+1.024	+0.103	<.001	.005	3	3
BRCA	GZMA →	+1.080	+0.110	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006501 vs PSORS1C3 — UCEC

Explore this scatter interactively →