C-terminal protein lipidation

Across TCGA cell cohorts, RNA activity of the C-terminal protein lipidation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAFB, ABR, and LAMP3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAFB grouped by C-terminal protein lipidation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAFB →	-0.151	-0.107	.005	.003	3	6
LIVER	ABR →	-0.403	-0.201	.002	.006	2	7
UPPER_AERODIGESTIVE_TRACT	LAMP3 →	-0.194	-0.191	.001	<.001	3	5
LIVER	POLM →	+0.538	+0.337	.001	<.001	3	5
CNS	CBLL1 →	-0.364	-0.157	<.001	<.001	3	5
CNS	PCDHB13 →	-0.207	-0.150	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAFB by C-terminal protein lipidation activity — LARGE_INTESTINE

Explore this box plot interactively →