C-terminal protein lipidation

Across TCGA patient cohorts, RNA activity of the C-terminal protein lipidation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATG7, CAST, and TBC1D5, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C-terminal protein lipidation activity versus ATG7 in BRCA (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATG7 →	+0.259	+0.040	.001	<.001	3	10
LUAD	CAST →	+0.389	+0.046	<.001	<.001	3	7
BRCA	TBC1D5 →	+0.164	+0.026	.007	.001	3	6
GBM	TOX4 →	-0.238	-0.063	.005	.001	3	6
LSCC	HCLS1 →	+0.361	+0.050	.007	.001	3	6
GBM	ATG5 →	+0.326	+0.091	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006501 vs ATG7 — BRCA

Explore this scatter interactively →