C-terminal protein lipidation

Across TCGA patient cohorts, RNA activity of the C-terminal protein lipidation pathway is significantly associated with the RNA expression of multiple genes, with the PCPG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG7, EMC3, and CYBB, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C-terminal protein lipidation activity versus ATG7 in PCPG (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PCPG	ATG7 →	+0.819	+0.063	<.001	<.001	3	31
PCPG	EMC3 →	+0.659	+0.060	<.001	<.001	3	27
UVM	CYBB →	+1.335	+0.037	<.001	<.001	3	27
SARC	FPR1 →	+1.231	+0.023	<.001	<.001	3	26
ACC	ARL8B →	+0.922	+0.037	<.001	<.001	3	26
CHOL	MTMR14 →	+0.723	+0.062	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006501 vs ATG7 — PCPG

Explore this scatter interactively →