C-terminal protein lipidation

Across TCGA cell cohorts, RNA activity of the C-terminal protein lipidation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DROSHA, KIAA1217, and MOB3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DROSHA grouped by C-terminal protein lipidation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DROSHA →	+0.586	+1.265	.009	.007	2	4
OESOPHAGUS	KIAA1217 →	-1.763	-1.595	.003	.008	3	3
LUNG_NSCLC_LUAD	MOB3B →	-1.741	-1.114	<.001	<.001	3	3
LUNG_NSCLC_LUAD	MORN5 →	+0.151	+0.640	.005	.007	3	3
BREAST	MB21D2 →	+0.901	+0.872	.006	.004	3	3
SOFT_TISSUE	C5orf22 →	+0.523	+1.503	.004	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DROSHA by C-terminal protein lipidation activity — CNS

Explore this box plot interactively →