Q-omics provides the consensus-scored ZNF398 profile across patient tissues and cancer cell-line models. ZNF398 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ZNF398 is differentially expressed in 14, with the highest sampling consensus in COAD. Additionally, ZNF398 RNA expression shows 20,835 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, COAD, and ACC as cancer lineages where ZNF398 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZNF398 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZNF398 survival associations across molecular data types. ZNF398 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (5) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZNF398 RNA expression–survival associations across cancer types. High ZNF398 expression shows unfavorable associations in KICH, MESO and ACC, but favorable associations in KIRC, HNSC and THYM. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for ZNF398 RNA expression.
This table summarizes ZNF398 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 2. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for ZNF398. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZNF398 shows lower tumor expression in THCA and higher tumor expression in COAD, BLCA, HNSC, LIHC and LUAD. The COAD box plot shows higher ZNF398 RNA expression in tumor versus normal tissue (log2 FC = +0.611, t-test p < 0.001).
This table shows molecular features associated with ZNF398 in patient tissues and cancer cell lines. In patient samples, ZNF398 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ZNF398 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BLOOD_Leukemia.
