Across TCGA cell cohorts, ZNF398 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF398-associated genes across cancer lineages are MINAR2, TIFAB, and GPR101. Each is linked with ZNF398 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF398-to-partner and partner-to-ZNF398 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF398→partner) and Y-score (partner→ZNF398) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MINAR2 →	+0.027	+2.882	.003	.005	3	2
SKIN	TIFAB →	+0.006	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	GPR101 →	+0.018	+4.887	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	TKTL2 →	+0.045	+4.509	<.001	<.001	3	1
LARGE_INTESTINE	ENPP6 →	+0.030	+3.378	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

ZNF398 survival (RNA) · tumor vs normal (RNA) · all ZNF398 data types