Across TCGA patient cohorts, ZNF398 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF398-associated genes across cancer lineages are eEF2, GATA6, and MEK1. Each is linked with ZNF398 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF398-to-partner and partner-to-ZNF398 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF398→partner) and Y-score (partner→ZNF398) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.388	+3.000	.024	.036	3	1
UCEC	GATA6 →	-0.169	-3.000	.029	.035	3	1
UCEC	MEK1 →	+0.389	+2.321	.027	.034	3	1
UCEC	MSH2 →	-0.279	-2.973	.012	.035	3	1
UCEC	mTOR_pS2448 →	-0.174	-2.980	.015	.036	3	1
UCEC	p27_pT198 →	+0.159	+2.459	.002	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

ZNF398 survival (RNA) · tumor vs normal (RNA) · all ZNF398 data types