Across TCGA patient cohorts, ZNF398 mutation is significantly associated with the RNA expression of many other genes, with 793 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF398-associated genes across cancer lineages are MIR489, GTF2IP3, and OR6U2P. Each is linked with ZNF398 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF398-to-partner and partner-to-ZNF398 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF398→partner) and Y-score (partner→ZNF398) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR489 →	+0.353	+8.471	<.001	.005	3	3
LUAD	GTF2IP3 →	+0.209	+4.576	.003	<.001	3	3
COAD	OR6U2P →	+0.029	+4.602	<.001	.003	3	2
UCEC	WHAMM →	+0.806	+3.616	<.001	.001	3	2
UCEC	SLAMF8 →	+0.856	+3.191	.001	.009	3	2
UCEC	DDX19A →	+0.406	+3.467	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 793 associations by consensus.

Exploration

ZNF398 survival (RNA) · tumor vs normal (RNA) · all ZNF398 data types