zinc finger protein 287Genealiases: ZKSCAN13 · ZSCAN45
Q-omics provides the consensus-scored ZNF287 profile across patient tissues and cancer cell-line models. ZNF287 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ZNF287 is differentially expressed in 11, with the highest sampling consensus in KICH. Additionally, ZNF287 protein abundance shows 25,507 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRC, KICH, and LSCC as cancer lineages where ZNF287 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZNF287 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZNF287 survival associations across molecular data types. ZNF287 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (5) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZNF287 RNA expression–survival associations across cancer types. High ZNF287 expression shows unfavorable associations in KICH and CESC, but favorable associations in KIRC, BRCA, LUAD and ACC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for ZNF287 RNA expression.
This table summarizes ZNF287 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 5. The strongest signals are observed in KICH for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for ZNF287. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZNF287 shows lower tumor expression in KICH, KIRC, THCA, COAD and UCEC and higher tumor expression in LIHC. The KICH box plot shows higher ZNF287 RNA expression in normal versus tumor tissue (log2 FC = −0.932, t-test p < 0.001).
This table shows molecular features associated with ZNF287 in patient tissues and cancer cell lines. In patient samples, ZNF287 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, ZNF287 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and BLOOD_Leukemia.
