ZNF287

Across TCGA patient cohorts, ZNF287 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF287-associated genes across cancer lineages are mTOR_pS2448, RAD51, and Src_pY416. Each is linked with ZNF287 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF287-to-partner and partner-to-ZNF287 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ZNF287-low versus ZNF287-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF287→partner) and Y-score (partner→ZNF287) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.132	-2.489	.006	.001	3	2
UCEC	RAD51 →	+0.114	+2.087	.012	.005	3	2
UCEC	Src_pY416 →	-0.157	-1.209	.044	.035	3	2
UCEC	ASNS →	+0.397	+2.321	<.001	.005	3	2
UCEC	CDK1 →	+0.159	+2.169	.001	.003	3	2
SKCM	Raptor →	-0.220	-3.169	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

mTOR_pS2448 by ZNF287 expression — UCEC

Explore this box plot interactively →