ubiquinol-cytochrome c reductase core protein 2Genealiases: MC3DN5 · QCR2 · UQCR2
Q-omics provides the consensus-scored UQCRC2 profile across patient tissues and cancer cell-line models. UQCRC2 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, UQCRC2 is differentially expressed in 12, with the highest sampling consensus in THCA. Additionally, UQCRC2 protein abundance shows 24,771 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRP, THCA, and GBM as cancer lineages where UQCRC2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UQCRC2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UQCRC2 survival associations across molecular data types. UQCRC2 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (7) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UQCRC2 RNA expression–survival associations across cancer types. High UQCRC2 expression shows unfavorable associations in UVM, but favorable associations in KIRP, KIRC, READ, LGG and MESO. The KIRP Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify KIRP as the clearest survival context for UQCRC2 RNA expression.
This table summarizes UQCRC2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 5. The strongest signals are observed in THCA for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for UQCRC2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UQCRC2 shows lower tumor expression in THCA, KIRC, COAD, HNSC and BLCA and higher tumor expression in CHOL. The THCA box plot shows higher UQCRC2 RNA expression in normal versus tumor tissue (log2 FC = −0.694, t-test p < 0.001).
This table shows molecular features associated with UQCRC2 in patient tissues and cancer cell lines. In patient samples, UQCRC2 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, UQCRC2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and UPPER_AERODIGESTIVE_TRACT.
