UQCRC2

Across TCGA patient cohorts, UQCRC2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UQCRC2-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and INPP4B. Each is linked with UQCRC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UQCRC2-to-partner and partner-to-UQCRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by UQCRC2-low versus UQCRC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UQCRC2→partner) and Y-score (partner→UQCRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.201	+2.820	.048	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.121	-3.160	.045	.019	3	1
UCEC	INPP4B →	-0.323	-3.169	.039	.018	3	1
UCEC	Ku80 →	+0.394	+3.598	<.001	.001	3	1
UCEC	p90 RSK →	+0.196	+2.999	.034	.035	3	1
UCEC	PDCD4 →	-0.463	-2.999	.042	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

eIF4E by UQCRC2 expression — UCEC

Explore this box plot interactively →