Q-omics provides the consensus-scored UNC5D profile across patient tissues and cancer cell-line models. UNC5D expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, UNC5D is differentially expressed in 10, with the highest sampling consensus in COAD. Additionally, UNC5D RNA expression shows 15,682 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight UVM, COAD, and TGCT as cancer lineages where UNC5D shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UNC5D — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UNC5D survival associations across molecular data types. UNC5D RNA expression shows survival associations in the most cancer types (22), followed by mutation status (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UNC5D RNA expression–survival associations across cancer types. High UNC5D expression shows unfavorable associations in UVM and LUAD, but favorable associations in KIRP, UCS, KIRC and ACC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for UNC5D RNA expression.
This table summarizes UNC5D tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for UNC5D. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UNC5D shows lower tumor expression in COAD, KIRC, READ, HNSC, THCA and STAD. The COAD box plot shows higher UNC5D RNA expression in normal versus tumor tissue (log2 FC = −0.297, t-test p < 0.001).
This table shows molecular features associated with UNC5D in patient tissues and cancer cell lines. In patient samples, UNC5D shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, UNC5D RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Myeloma and LARGE_INTESTINE.
