UNC5D

Across TCGA patient cohorts, UNC5D mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC5D-associated genes across cancer lineages are PKC-a_pS657, Cyclin-E1, and Cyclin-B1. Each is linked with UNC5D in more than 3 cancer types. Because this analysis shows association rather than direction, both UNC5D-to-partner and partner-to-UNC5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a_pS657 grouped by UNC5D-low versus UNC5D-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5D→partner) and Y-score (partner→UNC5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PKC-a_pS657 →	-0.322	-1.765	.004	.013	3	4
STAD	Cyclin-E1 →	+0.518	+3.000	.044	.036	3	3
UCEC	Cyclin-B1 →	+0.541	+2.321	<.001	<.001	3	3
BRCA	PTEN →	-0.475	-3.439	<.001	.005	3	3
UCEC	MEK1 →	+0.383	+1.788	<.001	<.001	3	3
UCEC	Shc_pY317 →	-0.127	-1.807	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

PKC-a_pS657 by UNC5D expression — LUAD

Explore this box plot interactively →