UNC5D

Across TCGA cell cohorts, UNC5D mutation is significantly associated with the RNA expression of many other genes, with 1,016 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UNC5D-associated genes across cancer lineages are OR11H1, GUCA1A, and ORC2. Each is linked with UNC5D in more than 1 cancer types. Because this analysis shows association rather than direction, both UNC5D-to-partner and partner-to-UNC5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H1 grouped by UNC5D-low versus UNC5D-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC5D→partner) and Y-score (partner→UNC5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	OR11H1 →	+0.016	+3.459	<.001	.004	3	2
OVARY	GUCA1A →	+0.047	+3.862	<.001	.005	3	2
LARGE_INTESTINE	ORC2 →	+0.529	+2.825	<.001	<.001	3	2
LUNG_NSCLC_LUAD	RLF →	+0.520	+3.321	<.001	.004	3	2
LUNG_NSCLC_LUAD	THOC2 →	+0.661	+3.584	<.001	<.001	3	2
LUNG_NSCLC_LUAD	C12orf65 →	+0.442	+3.843	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,016 associations by consensus.

OR11H1 by UNC5D expression — LIVER

Explore this box plot interactively →