Q-omics provides the consensus-scored TWIST1 profile across patient tissues and cancer cell-line models. TWIST1 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, TWIST1 is differentially expressed in 10, with the highest sampling consensus in HNSC. Additionally, TWIST1 RNA expression shows 15,556 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight KIRP, HNSC, and PDAC as cancer lineages where TWIST1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TWIST1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TWIST1 survival associations across molecular data types. TWIST1 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (4) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TWIST1 RNA expression–survival associations across cancer types. High TWIST1 expression shows unfavorable associations in KIRP, UVM, MESO, KIRC and LGG, but favorable associations in ACC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for TWIST1 RNA expression.
This table summarizes TWIST1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 4. The strongest signals are observed in LUAD for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for TWIST1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TWIST1 shows lower tumor expression in BRCA and higher tumor expression in HNSC, LUAD, COAD, LUSC and KIRC. The HNSC box plot shows higher TWIST1 RNA expression in tumor versus normal tissue (log2 FC = +2.225, t-test p < 0.001).
This table shows molecular features associated with TWIST1 in patient tissues and cancer cell lines. In patient samples, TWIST1 shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set. In cancer cell lines, TWIST1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in SKIN and SOFT_TISSUE.
