TWIST1

Across TCGA cell cohorts, TWIST1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,736 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TWIST1-associated GO terms across cancer lineages are Outer ear morphogenesis, Cerebral cortex tangential migration, and Protein depolymerization. Each is linked with TWIST1 in more than 15 cancer types. Because this analysis shows association rather than direction, both TWIST1-to-partner and partner-to-TWIST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Outer ear morphogenesis grouped by TWIST1-low versus TWIST1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TWIST1→partner) and Y-score (partner→TWIST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Outer ear morphogenesis →	+1.246	+2.121	<.001	<.001	3	16
BLOOD_Myeloma	Cerebral cortex tangential migration →	+1.244	+1.320	.003	.005	2	9
URINARY_TRACT	Protein depolymerization →	+0.118	+1.671	<.001	.001	3	8
CNS	Regulation of establishment of blood-brain barrier →	+0.835	+1.741	<.001	.003	3	7
UPPER_AERODIGESTIVE_TRACT	Serotonin secretion →	-1.575	-1.662	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Serotonin production involved in inflammatory response →	-1.575	-1.662	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,736 associations by consensus.

Outer ear morphogenesis by TWIST1 expression — CNS

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