TWIST1

Across TCGA cell cohorts, TWIST1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TWIST1-associated genes across cancer lineages are LBHD2, CDX4, and VSIG4. Each is linked with TWIST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TWIST1-to-partner and partner-to-TWIST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LBHD2 grouped by TWIST1-low versus TWIST1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TWIST1→partner) and Y-score (partner→TWIST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LBHD2 →	+0.143	+4.688	<.001	<.001	3	2
LARGE_INTESTINE	CDX4 →	+0.011	+4.217	<.001	.001	3	1
LARGE_INTESTINE	VSIG4 →	+0.027	+4.054	<.001	.004	3	1
LUNG_NSCLC_LUAD	GNG8 →	+0.424	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	FABP9 →	+0.049	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	IFNA14 →	+0.022	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

LBHD2 by TWIST1 expression — LARGE_INTESTINE

Explore this box plot interactively →