thrombospondin type laminin G domain and EAR repeatsGenealiases: C21orf29 · DFNB98 · ECTD14 · STHAG10 · TSP-EAR
Q-omics provides the consensus-scored TSPEAR profile across patient tissues and cancer cell-line models. TSPEAR expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, TSPEAR is differentially expressed in 14, with the highest sampling consensus in COAD. Additionally, TSPEAR RNA expression shows 12,268 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight COAD, and ACC as cancer lineages where TSPEAR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TSPEAR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TSPEAR survival associations across molecular data types. TSPEAR RNA expression shows survival associations in the most cancer types (19), followed by mutation status (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TSPEAR RNA expression–survival associations across cancer types. High TSPEAR expression shows unfavorable associations in COAD, KIRC, HNSC, ACC and LUSC, but favorable associations in PAAD. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for TSPEAR RNA expression.
This table summarizes TSPEAR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for TSPEAR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TSPEAR shows lower tumor expression in THCA and higher tumor expression in COAD, HNSC, LIHC, READ and STAD. The COAD box plot shows higher TSPEAR RNA expression in tumor versus normal tissue (log2 FC = +0.836, t-test p < 0.001).
This table shows molecular features associated with TSPEAR in patient tissues and cancer cell lines. In patient samples, TSPEAR shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, TSPEAR RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and BONE.
