TSPEAR

Across TCGA cell cohorts, TSPEAR mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSPEAR-associated genes across cancer lineages are C20orf85, PAX1, and DPP6. Each is linked with TSPEAR in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPEAR-to-partner and partner-to-TSPEAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by TSPEAR-low versus TSPEAR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPEAR→partner) and Y-score (partner→TSPEAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.018	+4.384	.001	.006	3	1
BLOOD_Leukemia	PAX1 →	+0.042	+4.060	<.001	.003	3	1
BLOOD_Leukemia	DPP6 →	+0.446	+4.108	<.001	.003	3	1
BLOOD_Leukemia	OR10R2 →	+1.174	+3.551	.005	.009	3	1
BLOOD_Leukemia	SRD5A2 →	+0.245	+3.855	<.001	.007	3	1
BLOOD_Leukemia	PRSS50 →	+0.036	+4.066	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

C20orf85 by TSPEAR expression — BLOOD_Leukemia

Explore this box plot interactively →