TSPEAR

Across TCGA patient cohorts, TSPEAR mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPEAR-associated genes across cancer lineages are STAT3_pY705, TFRC, and C-Raf. Each is linked with TSPEAR in more than 3 cancer types. Because this analysis shows association rather than direction, both TSPEAR-to-partner and partner-to-TSPEAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by TSPEAR-low versus TSPEAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPEAR→partner) and Y-score (partner→TSPEAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.336	-1.700	<.001	.001	3	4
SKCM	TFRC →	+0.527	+3.000	.025	.034	3	3
UCEC	C-Raf →	+0.166	+1.736	<.001	.006	3	3
UCEC	FASN →	+0.268	+2.115	.026	.016	3	2
UCEC	Notch1 →	+0.147	+1.700	<.001	.001	3	2
UCEC	p62 Lck ligand →	+0.282	+1.257	.004	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

STAT3_pY705 by TSPEAR expression — UCEC

Explore this box plot interactively →