TSPEAR

Across TCGA cell cohorts, TSPEAR RNA expression is significantly associated with the go_rna of many other GO terms, with 2,662 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TSPEAR-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Positive regulation of striated muscle contraction, and Heterochromatin formation. Each is linked with TSPEAR in more than 7 cancer types. Because this analysis shows association rather than direction, both TSPEAR-to-partner and partner-to-TSPEAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by TSPEAR-low versus TSPEAR-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPEAR→partner) and Y-score (partner→TSPEAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.068	+1.319	.008	<.001	3	8
BONE	Positive regulation of striated muscle contraction →	-0.245	-2.686	<.001	<.001	3	6
BONE	Heterochromatin formation →	+0.069	+1.947	.002	.001	3	6
BONE	Positive regulation of DNA recombination →	+0.131	+1.792	<.001	<.001	3	6
BONE	Positive regulation of RNA export from nucleus →	+0.087	+1.693	.001	<.001	3	6
LUNG_SCLC	Regulation of myoblast fusion →	+0.083	+1.416	.006	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,662 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by TSPEAR expression — LUNG_SCLC

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