TSPEAR

Across TCGA pan-cancer cohorts, TSPEAR Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated TSPEAR data layer compared with 19 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TSPEAR Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TSPEAR expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

MESO, SKCM, and SCLC are the cancer types where TSPEAR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.071	0.572	<.001	24	view →
SKCM	DFS	Median	III,IV	0.107	0.654	.003	13	view →
SCLC	DFS	Median	All	0.219	0.630	.012	12	view →
ESCA	DFS	Median	II,III,IV	0.163	0.525	.012	12	view →
HNSC	OS	Median	IV	0.156	0.641	.046	9	view →
GBM	DFS	Median	All	0.765	0.189	.013	6	view →
UCEC	DFS	Median	All	0.927	0.623	.024	6	view →
LIHC	DFS	Median	All	0.196	0.547	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TSPEAR–MESO (OS)

Open the MESO breakdown →