transmembrane protein 238 likeGenealiases: FORCP · LINC00675
Q-omics provides the consensus-scored TMEM238L profile across patient tissues and cancer cell-line models. TMEM238L expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, TMEM238L is differentially expressed in 12, with the highest sampling consensus in KIRC. Additionally, TMEM238L RNA expression shows 15,083 significant gene co-expression associations, with the highest sampling consensus in ESCA. Together, these results highlight LGG, KIRC, and ESCA as cancer lineages where TMEM238L shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMEM238L — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMEM238L survival associations across molecular data types. TMEM238L RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMEM238L RNA expression–survival associations across cancer types. High TMEM238L expression shows unfavorable associations in LGG, THYM and ESCA, but favorable associations in KIRP, BLCA and READ. The LGG Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for TMEM238L RNA expression.
This table summarizes TMEM238L tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for TMEM238L. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMEM238L shows lower tumor expression in KIRC, HNSC, COAD, KIRP, KICH and READ. The KIRC box plot shows higher TMEM238L RNA expression in normal versus tumor tissue (log2 FC = −3.491, t-test p < 0.001).
This table shows molecular features associated with TMEM238L in patient tissues and cancer cell lines. In patient samples, TMEM238L shows the broadest associations at the RNA and protein expression levels, with ESCA recurring as the lineage with the largest associated feature set. In cancer cell lines, TMEM238L RNA and mutation anchors are most strongly linked to RNA-expression features, especially in NCI60_ALL.
