TMEM238L

Across TCGA pan-cancer cohorts, TMEM238L RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM238L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM238L RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM238L is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where TMEM238L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM238L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−3.491	<.001	12	view →
HNSC	Female	IV	−2.571	<.001	12	view →
COAD	Female	III,IV	−2.009	<.001	12	view →
KIRP	Male	All	−3.312	<.001	11	view →
KICH	Female	II,III,IV	−4.105	<.001	10	view →
READ	All	All	−2.111	<.001	7	view →
THCA	All	All	−0.116	<.001	5	view →
PRAD	All	All	−1.607	<.001	2	view →
BRCA	Female	All	−0.324	.016	2	view →
LUAD	Female	III,IV	−0.161	.001	2	view →
STAD	Male	IV	−5.170	.032	1	view →
LUSC	All	All	+0.440	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEM238L–KIRC

Open the KIRC breakdown →