TMEM238L

Across TCGA pan-cancer cohorts, TMEM238L RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TMEM238L data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TMEM238L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM238L expression acts as an unfavorable survival marker, although some lineages such as KIRP and BLCA show a favorable association.

LGG, KIRP, and THYM are the cancer types where TMEM238L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.314	0.484	<.001	47	view →
KIRP	DFS	Median	IV	0.594	0.038	.004	32	view →
THYM	OS	Quartile	II,III,IV	0.534	1.000	.004	30	view →
BLCA	OS	Median	II,III,IV	0.761	0.656	.007	26	view →
ESCA	OS	Quartile	All	0.375	1.000	.006	26	view →
READ	OS	Tertile	II,III,IV	1.000	0.727	.011	24	view →
MESO	OS	Tertile	IV	0.868	0.375	.004	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
HNSC	OS	Tertile	All	0.826	0.598	.002	17	view →
SKCM	OS	Median	IV	0.867	0.244	.006	16	view →
THCA	OS	Tertile	II,III,IV	0.913	1.000	.002	16	view →
LUAD	DFS	Median	II,III,IV	0.324	0.534	.014	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TMEM238L–LGG (DFS)

Open the LGG breakdown →