TMEM238L

Across TCGA patient cohorts, TMEM238L RNA expression is significantly associated with the go_rna of many other GO terms, with 7,130 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible TMEM238L-associated GO terms across cancer lineages are L-leucine catabolic process, Organophosphate catabolic process, and Potassium ion export across plasma membrane. Each is linked with TMEM238L in more than 14 cancer types. Because this analysis shows association rather than direction, both TMEM238L-to-partner and partner-to-TMEM238L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-leucine catabolic process grouped by TMEM238L-low versus TMEM238L-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM238L→partner) and Y-score (partner→TMEM238L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	L-leucine catabolic process →	+0.036	+0.372	<.001	<.001	2	15
ESCA	Organophosphate catabolic process →	+0.032	+1.842	<.001	<.001	3	14
ESCA	Potassium ion export across plasma membrane →	+0.115	+2.638	<.001	<.001	3	13
PAAD	Nucleoside diphosphate metabolic process →	+0.030	+1.085	<.001	<.001	3	13
TGCT	Ribonucleoside diphosphate catabolic process →	+0.064	+0.412	<.001	<.001	3	13
ESCA	Nucleoside bisphosphate metabolic process →	+0.031	+1.057	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,130 associations by consensus.

L-leucine catabolic process by TMEM238L expression — LAML

Explore this box plot interactively →