TMEM238L

Across TCGA patient cohorts, TMEM238L mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM238L-associated genes across cancer lineages are FSCB, RNA5SP361, and SNORA80C. Each is linked with TMEM238L in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM238L-to-partner and partner-to-TMEM238L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSCB grouped by TMEM238L-low versus TMEM238L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM238L→partner) and Y-score (partner→TMEM238L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FSCB →	+0.080	+4.348	<.001	.001	3	1
UCEC	RNA5SP361 →	+0.355	+4.877	<.001	.003	3	1
UCEC	SNORA80C →	+0.591	+5.063	<.001	<.001	3	1
UCEC	RNA5SP358 →	+0.606	+3.935	<.001	.003	3	1
UCEC	RNA5SP463 →	+0.812	+3.258	<.001	.009	3	1
UCEC	RNU5E-8P →	+0.422	+4.186	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

FSCB by TMEM238L expression — UCEC

Explore this box plot interactively →