transmembrane protein 204Genealiases: C16orf30 · CLP24
Q-omics provides the consensus-scored TMEM204 profile across patient tissues and cancer cell-line models. TMEM204 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, TMEM204 is differentially expressed in 15, with the highest sampling consensus in KICH. Additionally, TMEM204 RNA expression shows 18,824 significant protein co-abundance associations, with the highest sampling consensus in CCRCC. Together, these results highlight KIRC, KICH, and CCRCC as cancer lineages where TMEM204 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMEM204 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMEM204 survival associations across molecular data types. TMEM204 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMEM204 RNA expression–survival associations across cancer types. High TMEM204 expression shows unfavorable associations in KIRP, but favorable associations in KIRC, UCEC, UVM, LIHC and HNSC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for TMEM204 RNA expression.
This table summarizes TMEM204 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 2. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for TMEM204. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMEM204 shows lower tumor expression in KICH, KIRP, LUAD and LUSC and higher tumor expression in HNSC and KIRC. The KICH box plot shows higher TMEM204 RNA expression in normal versus tumor tissue (log2 FC = −2.210, t-test p < 0.001).
This table shows molecular features associated with TMEM204 in patient tissues and cancer cell lines. In patient samples, TMEM204 shows the broadest associations at the RNA and protein expression levels, with CCRCC recurring as the lineage with the largest associated feature set. In cancer cell lines, TMEM204 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in BONE and BLOOD_Leukemia.
