TMEM204

Across TCGA pan-cancer cohorts, TMEM204 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM204’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TMEM204 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM204 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, HNSC, and KIRP are the cancer types where TMEM204 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM204 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.210	<.001	11	view →
HNSC	Female	III,IV	+1.707	<.001	11	view →
KIRP	Male	All	−2.435	<.001	9	view →
LUAD	Female	III,IV	−2.103	<.001	9	view →
KIRC	Female	All	+1.144	<.001	9	view →
LUSC	Female	All	−2.395	<.001	8	view →
UCEC	All	All	−1.820	<.001	6	view →
BLCA	Male	III,IV	−0.819	.006	6	view →
COAD	All	All	+0.517	.002	6	view →
THCA	All	IV	−1.327	.011	4	view →
LIHC	Female	All	+0.869	<.001	4	view →
BRCA	All	All	−0.276	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TMEM204–KICH

Open the KICH breakdown →