TMEM204

Across TCGA patient cohorts, TMEM204 mutation is significantly associated with the RNA expression of many other genes, with 1,844 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM204-associated genes across cancer lineages are LIN7C, HSD17B12, and COX15. Each is linked with TMEM204 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM204-to-partner and partner-to-TMEM204 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIN7C grouped by TMEM204-low versus TMEM204-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM204→partner) and Y-score (partner→TMEM204) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIN7C →	+0.767	+3.502	<.001	.002	3	1
UCEC	HSD17B12 →	+0.659	+2.700	<.001	.006	3	1
UCEC	COX15 →	+0.572	+3.708	<.001	<.001	3	1
UCEC	NPAT →	+0.625	+3.343	<.001	.005	3	1
UCEC	AASDHPPT →	+0.573	+2.254	.004	.006	3	1
UCEC	EI24 →	+0.489	+3.364	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,844 associations by consensus.

LIN7C by TMEM204 expression — UCEC

Explore this box plot interactively →