TMEM204

Across TCGA patient cohorts, TMEM204 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM204-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and MEK1. Each is linked with TMEM204 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM204-to-partner and partner-to-TMEM204 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TMEM204-low versus TMEM204-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM204→partner) and Y-score (partner→TMEM204) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.123	-1.986	.006	.032	3	1
UCEC	eIF4E →	+0.240	+2.820	.011	.035	3	1
UCEC	MEK1 →	+0.433	+2.000	.008	.032	3	1
UCEC	MSH6 →	-0.563	-3.311	<.001	.010	3	1
UCEC	Notch1 →	+0.182	+2.000	.004	.032	3	1
UCEC	SCD →	-0.144	-3.156	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by TMEM204 expression — UCEC

Explore this box plot interactively →