transmembrane channel like 1Genealiases: DFNA36 · DFNB11 · DFNB7
Q-omics provides the consensus-scored TMC1 profile across patient tissues and cancer cell-line models. TMC1 expression is associated with patient survival in 29 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, TMC1 is differentially expressed in 9, with the highest sampling consensus in KICH. Additionally, TMC1 RNA expression shows 15,383 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight HNSC, KICH, and TGCT as cancer lineages where TMC1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMC1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMC1 survival associations across molecular data types. TMC1 RNA expression shows survival associations in the most cancer types (29), followed by mutation status (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMC1 RNA expression–survival associations across cancer types. High TMC1 expression shows unfavorable associations in ACC, BRCA and UVM, but favorable associations in HNSC, ESCA and KIRC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for TMC1 RNA expression.
This table summarizes TMC1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for TMC1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMC1 shows lower tumor expression in KICH, KIRP, KIRC and BRCA and higher tumor expression in LUAD and LUSC. The KICH box plot shows higher TMC1 RNA expression in normal versus tumor tissue (log2 FC = −0.630, t-test p < 0.001).
This table shows molecular features associated with TMC1 in patient tissues and cancer cell lines. In patient samples, TMC1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, TMC1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in URINARY_TRACT and LARGE_INTESTINE.
